Dissertation Behandlung von Osteoarthritis

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A randomised controlled clinical trial of the efficacy and safety of a standardised willow bark extract in the treatment of osteoarthritis of the hip and the knee. JavaScript is disabled for your browser. Some features of this site may not work without it. Eine randomisierte, kontrollierte klinische Studie zur Wirksamkeit und Verträglichkeit eines standardisierten Weidenrindenextraktes in der Behandlung von Cox- und Gonarthrosen A randomised controlled clinical trial of the efficacy and safety of a standardised willow bark extract in the treatment of osteoarthritis of the hip and the knee Biegert, Claudia.

Bitte warten Als pflanzliches Arzneimittel zur Arthrosetherapie wird in Deutschland unter anderem Weidenrinde WR verwendet, die von der Kommission E des ehemaligen Bundesgesundheitsamtes für die Behandlung von rheumatischen Beschwerden, fieberhaften Erkrankungen und Kopfschmerzen befürwortet wurde.

Von Schmid et al. Unterschiede zeigten sich in den genuinen Inhaltsstoffen der WR-Extrakte. Es wurde eine kontrollierte, randomisierte dreiarmige Doppelblindstudie im Parallelgruppendesign durchgeführt. Eingeschlossen wurden Patienten, die an einer nach den ACR-Kriterien verifizierbaren Cox- oder Gonarthrose litten und einen Mindestschmerzwert aufwiesen.

In der Auswertung der Nebenzielkriterien zeigte sich ebenfalls kein statistisch auffälliger Unterschied zugunsten der WR. Der Weidenrindenextrakt zeigte eine gute Verträglichkeit. Bei Dissertation Behandlung von Osteoarthritis Patienten traten unter Diclofenactherapie zwei schwerwiegende Unerwünschte Dissertation Behandlung von Osteoarthritis auf.

Weiterhin waren Veränderungen im roten Blutbild und eine Erhöhung der Leberwerte in der Diclofenacgruppe statistisch auffällig. Abstract: Drug therapy of osteoarthritis comprises mainly the use of non-steroidal antirheumatic drugs NSAIDs and analgesics. In Germany, willow bark is a Dissertation Behandlung von Osteoarthritis medicine used in the treatment of osteoarthritis which has been approved by the Commission E of the former Federal Health Agency in the treatment of rheumatic complaints, feverish conditions and headache.

Results from several clinical trials indicate an analgesic efficacy of willow bark extract. Schmid et al. The aim of the present study was to examine the efficacy of willow bark extract against placebo and standard treatment diclofenac in an out-patient-setting over 6 weeks. The preparations showed good conformity in the total content of salicin There were differences in the genuine substances contained in the willow bark extracts. The extract of the present trial contained picein 1.

The preparation of 25 Dissertation Behandlung von Osteoarthritis diclofenac enteric coated used in the present clinical trial was analysed according to USP There was no dissolution after two hours in 0,1 N HCl, after 45 min in phosphate buffer pH 6. A controlled, randomised double-blind three-armed clinical trial with parallel design was carried Dissertation Behandlung von Osteoarthritis.

Patients with a diagnosis of osteoarthritis of the hip or the knee verified by the ACR-Criteria and a minimal pain score were included in the trial. NSAIDs, analgesics and corticoisteroids had to be discontinued Dissertation Behandlung von Osteoarthritis to enrollment. An analysis of covariance ANCOVA showed no statistically significant difference between willow bark and placebo estimated difference in favour of willow bark: None of the secondary outcome measures showed statistically significant differences between willow bark and placebo.

Between diclofenac and placebo, there was a statistically significant difference in favour of diclofenac in nearly all of the outcome measures estimated difference in WOMAC pain score: Willow bark extract was well tolerated. In the willow bark group, 38 adverse events were Dissertation Behandlung von Osteoarthritis, versus 84 in the diclofenac group and 51 in the placebo group. One patient in the diclofenac group experienced two serious adverse events. Additionally, changes in red blood count and an increase in liver enzymes were statistically significant Dissertation Behandlung von Osteoarthritis the diclofenac group.

In the present study, standardised willow bark extract did not show analgesic efficacy using the primary outcome measure WOMAC pain. The validity of the study was confirmed by comparing diclofenac with placebo. Contact Contracts Help. University Library Imprint Datenschutz. KB PDF. PhytotherapeutikumWeidenrindenextraktÄquivalenzuntersuchungen Randomised controlled trialosteoarthritiswillow bark extractequivalence tests.